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New Cancer Drug?
The Brazilian Wasp Venom that Cures Cancer
Polybia paulista is a wasp that is the latest addition to the growing list of pests found to help humankind in not so obvious ways. Researchers in the UK and Brazil have found that the venom produced by the social wasp to protect itself from enemies, has a potential role in the fight against cancer in human beings.
Mention the word ‘wasp,’ and the mind conjures up visions of buzzing, flying insects with a sting that makes you go numb with pain. In fact, the pest control agencies get a fairly large number of calls seeking help to eliminate wasps from homes and business establishment.
Naturally, we usually equate pests with nuisance and health problems. But thanks to modern scientific research, we are discovering some of the advantages that pests bring into our daily lives. The self-protection mechanism of insects and animals is most evident in the form of venom that they inject into their enemies.
Polybia paulista is a wasp that is the latest addition to the growing list of pests found to help humankind in not so obvious ways. A combined study by researchers in the UK and Brazil has found that the venom produced by the social wasp to protect itself from enemies, has a potential role in the fight against cancer in human beings.
Yes, you heard it right. Wasp venom is a potential cancer buster according to a study published in Biophysical Journal. The study reveals that MP1 (Polybia-MP1), the toxin in the venom, targets only cancerous cells and doesn’t affect normal cells in the body.
MP1 creates holes on the surface of cancer affected cells, allowing the crucial molecules emerge from within and stimulate the cells to function. MP1 achieves this by interacting with the abnormally distributed lipids on the cell surfaces. The discovery opens up immense possibilities in the war that humans wage against the relentless onslaught of cancer.
According to Paul Beales of the University of Leeds, UK, who co-authored the study, the discovery paves the way for the development of a new class of anticancer drugs that can be used in combination with other drugs to target different parts of cancer cells simultaneously.
How the Wasp Venom Kills Cancer Cells
While the study shows that the toxin in the venom is useful in fighting cases of prostate and bladder cancer, there is no clarity on how exactly MP1 acts so selectively against cancerous cells alone without harming normal human cells.
The authors suspect that the key lies within the membranes of the cancer cells itself. It was noticed that unlike healthy cells where phospholipids are located in the internal membrane leaflet, in cancer cells the phospholipids are located in the external membrane and accessible to MP1. The phospholipids typically are of two types: phosphatidylserine (PS) and phosphatidylethanolamine (PE).
To test the validity of the theory, the scientists created model membranes, embedded some of them with phospholipids, and exposed them to MP1. A wide range of biophysical and imaging techniques was used to simulate the debilitating effects of MP1 on the membranes. Interestingly, the PS phospholipids improved the bonding ability of MP1 to the membrane by as much as 8 times.
Similarly, the PE phospholipids also improved its ability to create gaping holes in the membrane, by around 20 times. It was noticed that within seconds, crucial molecules like RNA and proteins were able to emerge from to the surface, enabling the cell to function normally.
New Anti-Cancer Treatment
Going forward, the scholars intend to study the relation between the peptide structure and its function to mold its potency and selectivity for clinical usage. The discovery opens up huge possibilities considering that the peptide is biased towards cancer cells and benign towards non-normal cells.
Conventional cancer treatments like radiation and chemotherapy come with the threat of collateral damage. However, with the discovery of options like MP1 in wasp venom, the trend is likely to shift to safer treatment methods where healthy cells are not affected at all. This also means the chances of cancer survival increase drastically.***
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Celebrate April as National Pest Management Month
For over 30 years the National Pest Management Association (NPMA) has celebrated the courageous men and women working tirelessly in the Pest Control Management industry during April.
Considering all the work, training and dedication that is involved, these passionate professionals truly deserve a noteworthy appreciation and acknowledgment for the hard work they perform daily.
Pest Risk Analysis & Assessment
Pests have plagued our homes and businesses for centuries. They do more than give people a case of the crawlies and heebie-jeebies. They can potentially cause excessive damage that can impact your bank account heavily, or transmit diseases, bacteria, germs, and contribute additional allergen particulates.
Professionals in the pest control industry have accomplished a remarkable contribution in managing pest populations and rescuing home and business owners from stressful situations from an assortment of insects, rodents, wildlife, and birds inflicting their property.
Pest Inspections & Control
Insects such as bees, hornets, and wasps can be a real hindrance on outdoor activities, especially for those severely allergic. Thanks to the brave experts in pest control; stinging insects are relocated away from the festivities.
Mosquitoes, bed bugs, ticks, fleas and other bloodsuckers are quickly abolished with pest control professionals trained to execute inspections and locate colonies or nests. Termites, carpenter ants, rodents and other nuisance wildlife members are stopped in their damaging tracks.
Homes and businesses are liberated from the destructive force these pests inflict on the warriors that fight the good fight in the pest control industry. In a nutshell, those that chose to protect as a part of the pest control soldiers are doing the country a huge favor in preserving our homes, businesses and loved ones from the corruption of pests.
“Insects such as bees, hornets, and wasps can be a real hindrance on outdoor activities, especially for those severely allergic. Thanks to the brave experts in pest control; stinging insects are relocated away from the festivities.”
Tips to Prevent Pests in Your House
April is designated to observe their aid and to offer a little recognition and appreciation. In honor of Pest Control Management Month, we at Control Exterminating would like to offer some tips to contribute to minimizing pest intrusion in your home:
- Install or replace weather stripping along doors and windows to ensure they are properly sealed.
- Appropriately seal any holes, gaps, and cracks on the exterior of your home. From top to bottom, check the home for any entry points. Service pipes or vents should be guarded as well to prevent critters from gaining entrance to your home.
- Keep firewood stacked away from home, along with any cluttered, useful materials.
- Dispose of refuse piling up; keep lids tightly secured on trash bins. Keep trees, bushes, grass and other vegetation neatly trimmed and pruned away from home.
- Contain any leaks or standing water sources.
- Avoid leaving pet food out for long periods of time.
- Inside your home, repair leaky pipes or faucets to remove water sources or damp conditions pests find favorable.
- Remove clutter by donating the things you do not want. Discard trash, recycle the reusable items, and neatly put your belongings away in an organized fashion.
- Keep trash lids secure on the garbage cans and be sure to clean them out periodically.
- Clean cupboards and pantries. Dispose of fallen crumbs and spilled food and ingredients and seasonings.
- Properly contain food in sealable containers. Avoid leaving food packaged in cardboard, paper or flimsy plastic pests can easily gnaw through.
Call Control Exterminating to schedule a maintenance routine to keep them out of your Manhattan, NY home.***